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Recent Advances in Diagnostic Approaches for Mucormycosis
Jawad Safiia1, Marco Aurelio Díaz1,2,3, Hassan Alshaker1,3
1Brigham and Women's Hospital, Boston, MA 02115, USA.
Journal of Fungi (Basel, Switzerland)
|October 25, 2024
Summary
Rapid diagnosis of mucormycosis, a severe fungal infection, is crucial. This review covers traditional and advanced diagnostic methods, highlighting the need for timely and accurate identification to improve patient outcomes.
Area of Science:
- Mycology
- Infectious Diseases
- Diagnostic Medicine
Background:
- Mucormycosis is a life-threatening invasive fungal infection caused by Mucorales.
- Delayed diagnosis of mucormycosis leads to rapid progression and poor outcomes.
Purpose of the Study:
- To provide a comprehensive review of current and emerging diagnostic approaches for mucormycosis.
- To emphasize the critical need for rapid and accurate diagnosis.
Main Methods:
- Review of traditional methods: histopathology and culture.
- Exploration of advanced techniques: molecular assays, imaging, serology, and metabolomics.
- Discussion of diagnostic challenges.
Main Results:
- Latest advancements in mucormycosis diagnostics are presented.
- Comparison of traditional versus novel diagnostic strategies.
- Identification of key challenges in timely diagnosis.
Conclusions:
- Accurate and rapid diagnosis of mucormycosis is essential for effective management.
- Emerging diagnostic tools offer promise for earlier detection.
- Addressing diagnostic challenges is vital for improving patient survival rates.
Keywords:
Mucoralesfungal biomarkersmedical mycologymetabolomicsmucormycosisvolatile organic compounds
