Bio-Calcium from Skipjack Tuna Frame Attenuates Bone Loss in Ovariectomy-Induced Osteoporosis Rats
Jirakrit Saetang1, Acharaporn Issuriya2, Watcharapol Suyapoh3
1International Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand.
Marine Drugs
|October 25, 2024
Summary
Fish-derived bio-calcium from skipjack tuna frames shows promise for osteoporosis prevention. This natural calcium source effectively combats bone loss in ovariectomized rats, offering a potential alternative to conventional treatments.
Area of Science:
- Biochemistry
- Orthopedics
- Nutritional Science
Background:
- Osteoporosis poses a significant public health challenge, characterized by reduced bone mass and increased fracture risk.
- Current treatments for osteoporosis have limitations, driving the search for novel, effective therapeutic agents.
- Bio-calcium derived from fish frames presents a potential source of highly bioavailable calcium for bone health.
Purpose of the Study:
- To investigate the efficacy of bio-calcium derived from skipjack tuna frames in preventing bone loss in an established rat model of osteoporosis.
- To compare the bone-protective effects of tuna bio-calcium with calcium carbonate and estrogen treatments.
Main Methods:
- Tuna bio-calcium was extracted and purified using enzymatic hydrolysis, defatting, bleaching, and grinding.
- Calcium bioavailability was assessed using the Caco-2 cell monolayer model.
- Ovariectomized (OVX) rats were divided into groups receiving no treatment, estrogen, calcium carbonate, or tuna bio-calcium for eight weeks.
Main Results:
- Tuna bio-calcium demonstrated higher calcium absorption (13%) compared to calcium carbonate (10%) in vitro.
- Tuna bio-calcium significantly increased bone volume per tissue volume (BV/TV) in the femur (26%) and tibia (29%) compared to the OVX group.
- Treatment with tuna bio-calcium led to increased trabecular thickness and a marked reduction in osteoclast numbers in the femur and tibia.
Conclusions:
- Bio-calcium derived from skipjack tuna frames effectively mitigates bone loss in an ovariectomized rat model.
- Tuna bio-calcium exhibits superior bioavailability and bone-protective effects compared to calcium carbonate.
- This fish-derived bio-calcium represents a promising natural alternative for osteoporosis management and prevention.
Related Concept Videos
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:25Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
01:31Osteoclasts in Bone Remodeling
2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
01:40Bone Remodeling
38.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.2K