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Toxicological Characteristics Of Bacterial Nanocellulose In An In Vivo Experiment-part 2: Immunological Endpoints, Influence On The Intestinal Barrier And Microbiome.

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Toxicological Characteristics Of Bacterial Nanocellulose In An In Vivo Experiment-part 2: Immunological Endpoints, Influence On The Intestinal Barrier And Microbiome.

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Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment-Part 2: Immunological Endpoints,

Vladimir A Shipelin¹, Ekaterina A Skiba², Vera V Budaeva²

¹Federal Research Centre of Nutrition and Biotechnology, 109240 Moscow, Russia.

Nanomaterials (Basel, Switzerland)

|October 25, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Keywords:

anaphylaxis bacterial cellulose cytokines intestinal barrier intestinal microbiome lymphocytes nanofibers rats toxicity

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Bacterial nanocellulose (BNC) consumption in rats showed no adverse effects on immune function or allergic sensitization. Further research suggests potential prebiotic effects of BNC on the gut microbiome.

Area of Science:

Immunology
Microbiology
Toxicology
Food Science

Background:

Bacterial nanocellulose (BNC) is a potential substitute for microcrystalline cellulose and an ingredient in low-calorie foods.
The safety of dietary BNC consumption, particularly its impact on gut health and immune responses, requires thorough investigation.

Purpose of the Study:

To evaluate the subacute effects of dietary Bacterial nanocellulose (BNC) on rat immune function, intestinal microbiome, barrier integrity, and allergic sensitization.
To determine the non-observed adverse effect level (NOAEL) for BNC in a dietary context.

Main Methods:

Male Wistar rats were fed diets containing BNC (1-100 mg/kg body weight) for eight weeks.
Assessed serum cytokines, adipokines, intestinal fatty acid-binding protein 2 (iFABP2), cellular immunity indicators, gut microbiome composition, and ileal histology.

Evaluated systemic anaphylaxis and IgG antibody responses to food antigen in a separate four-week experiment.

Main Results:

BNC consumption did not exacerbate systemic anaphylaxis or alter IgG antibody responses at 100 mg/kg.
The non-observed adverse effect level (NOAEL) for BNC was determined to be less than 100 mg/kg/day based on immune function.
Observed no dose-dependent effects of BNC on the gut microbiome or intestinal mucosal barrier, with indications of potential prebiotic activity.

Conclusions:

Dietary Bacterial nanocellulose (BNC) appears safe for consumption at the tested doses, with no negative impact on immune function or allergic responses.
BNC may possess prebiotic properties, influencing the gut microbiome composition.
Further studies are warranted to fully elucidate the long-term effects and specific mechanisms of BNC's interaction with the host.