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Skin Permeability of Perfluorocarboxylic Acids Using Flow-Through Diffusion on Porcine Skin.

Andrew Stephen Hall1, Ronald Baynes2, Laura M Neumann2

  • 1Textile Protection and Comfort Center, Wilson College of Textiles, North Carolina State University, Raleigh, NC 27606, USA.

Toxics
|October 25, 2024
PubMed
Summary

Per- and polyfluoroalkyl substances (PFAS) can be absorbed through the skin, with smaller molecules like perfluorobutanoic acid (PFBA) showing higher permeability. These chemicals may accumulate in skin, creating a reservoir.

Keywords:
dermal absorptionflow-through diffusionperfluorocarboxylic acidsporcine skin

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Area of Science:

  • Environmental Science
  • Toxicology
  • Dermatology

Background:

  • Per- and polyfluoroalkyl substances (PFAS) are widely used in consumer and occupational products.
  • PFAS exposure is a concern due to potential health risks, including immunosuppression and carcinogenicity (e.g., PFOA).
  • Dermal exposure is a potential route of entry for PFAS into the body.

Purpose of the Study:

  • To characterize the dermal absorption of specific PFAS compounds.
  • To investigate the influence of molecular size and vehicle on PFAS skin permeability.
  • To assess the potential for PFAS to form reservoirs within the skin.

Main Methods:

  • Utilized *in vitro* flow-through diffusion systems with porcine skin.
  • Measured skin permeabilities of 14C-labeled perfluorooctanoic acid (PFOA), perfluorohexanoic acid (PFHxA), and perfluorobutanoic acid (PFBA).
  • Conducted tests over 8 hours using acetone or artificial perspirant as dosing vehicles.

Main Results:

  • PFBA demonstrated higher skin permeability compared to PFHxA, correlating with smaller molecular weight.
  • The choice of dosing vehicle (acetone vs. artificial perspirant) did not significantly affect permeability rates.
  • Dosing vehicles influenced the disposition of PFAS within the skin model.
  • Observed low overall permeability rates for these PFAS through the skin membranes.

Conclusions:

  • PFAS exhibit low dermal absorption rates but can persist in the skin, potentially acting as a reservoir.
  • Understanding dermal absorption is crucial for assessing occupational and consumer exposure risks.
  • Further research is needed to fully elucidate the long-term implications of skin-based PFAS accumulation.