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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Behavioral disorders in Parkinson disease: current view.

Kurt A Jellinger1

  • 1Institute of Clinical Neurobiology, Alberichgasse 5/13, 1150, Vienna, Austria. kurt.jellinger@univie.ac.at.

Journal of Neural Transmission (Vienna, Austria : 1996)
|October 25, 2024
PubMed
Summary

Parkinson disease (PD) patients often develop behavioral symptoms like anxiety and sleep disorders, impacting quality of life. These changes stem from neurodegeneration and altered brain connectivity, requiring further research for better treatments.

Keywords:
AnxietyApathyBehavioral impairmentBrain network dysfunctionsDisinhibitionImpulse control disorderNeuroimagingObsessive–compulsive symptomsParkinson diseaseREM sleep behavior disorder

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Area of Science:

  • Neurology
  • Neuroscience
  • Psychiatry

Background:

  • Parkinson disease (PD) is frequently accompanied by behavioral symptoms, including anxiety, apathy, and sleep disorders.
  • These symptoms affect 30-70% of PD patients and can precede motor symptom onset.
  • Behavioral changes in PD are linked to brain atrophy, neurotransmitter deficits, and altered neural connectivity.

Purpose of the Study:

  • To review recent literature on behavioral disturbances in Parkinson disease.
  • To focus on epidemiology, clinical features, risk factors, and neurobiological underpinnings.
  • To explore treatment options for these prevalent symptoms.

Main Methods:

  • Literature review of recent studies on PD behavioral symptoms.
  • Analysis of epidemiological data, clinical presentations, and risk factors.
  • Examination of neuroimaging findings and pathophysiological mechanisms.

Main Results:

  • Behavioral symptoms in PD are diverse and prevalent, impacting patient quality of life.
  • These symptoms are associated with specific patterns of brain atrophy and neurochemical changes.
  • The neurobiological basis involves multi-system neurodegeneration and altered network connectivity.

Conclusions:

  • Behavioral symptoms are a significant and early feature of Parkinson disease.
  • Understanding the neurobiological basis is crucial for developing effective interventions.
  • Further research is needed to elucidate the full clinical relevance and treatment strategies.