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Perinatal autopsy: its clinical value.

P R Meier, D K Manchester, R H Shikes

    Obstetrics and Gynecology
    |March 1, 1986
    PubMed
    Summary
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    Routine autopsies in perinatal deaths significantly improve diagnostic accuracy. Autopsies identified the cause of death in 26% of cases and highlighted the need for genetic counseling in 48% of cases.

    Area of Science:

    • Perinatal Medicine
    • Pathology
    • Medical Genetics

    Background:

    • Perinatal mortality remains a significant concern.
    • Accurate determination of the cause of death is crucial for clinical management and genetic counseling.
    • Clinical diagnoses may not always reflect the true cause of death in perinatal cases.

    Purpose of the Study:

    • To evaluate the clinical value of routine autopsies in perinatal deaths.
    • To compare clinically assigned causes of death with autopsy findings.
    • To assess the role of autopsy in identifying the need for genetic counseling.

    Main Methods:

    • Retrospective analysis of 172 sequential perinatal death cases.
    • Comparison of clinical diagnoses with autopsy results in 139 autopsied cases (52 fetal, 87 neonatal).

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  • Assessment of autopsy findings for identifying causes of death and genetic counseling needs.

    • Main Results:

    • Autopsies were performed in 81% (139/172) of perinatal deaths.
    • Autopsy was the sole means of establishing the cause of death in 26% of cases (9 fetal, 27 neonatal).
    • The need for genetic counseling was identified in 62 cases (48%), with autopsy being the sole source of this information in 30 cases.

    Conclusions:

    • Routine autopsies are invaluable in perinatal medicine, providing definitive causes of death.
    • Autopsies correct clinical impressions and are essential for identifying genetic factors requiring counseling.
    • Autopsy findings significantly contribute to clinical decision-making and family support in perinatal loss.