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Updated: Jun 9, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Addressing urgent priorities in antibiotic development: insights from WHO 2023 antibacterial clinical pipeline

Daniela Melchiorri1, Tamarie Rocke2, Richard A Alm3

  • 1Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy; AMR Division, World Health Organization, Geneva, Switzerland.

The Lancet. Microbe
|October 25, 2024
PubMed

Insights

Antimicrobial resistance is a global health crisis, especially impacting young children. This study assesses new antibiotics against priority pathogens to address critical research and development gaps.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Antimicrobial resistance (AMR) is a significant global health threat, leading to millions of deaths annually.
  • Children under five are particularly vulnerable to AMR-related infections.
  • Current antimicrobial research and development (R&D) is insufficient compared to other major diseases.

Purpose of the Study:

  • To evaluate the efficacy of current and novel antibiotics against the World Health Organization's (WHO) 2024 bacterial priority pathogens list.
  • To identify gaps and guide future R&D efforts in the antibacterial drug pipeline.
  • To monitor evolving resistance patterns and emerging resistance mechanisms.

Main Methods:

  • Analysis of the global antibacterial clinical pipeline.
  • Evaluation of antibiotic activity against the 2024 WHO bacterial priority pathogens.
  • Trend analysis of R&D output and innovation potential.

Main Results:

  • The study highlights persistent gaps in the development of effective antibacterial drugs.
  • Evolving resistance patterns necessitate continuous evaluation of antibiotic efficacy.
  • The 2024 WHO priority pathogens list reflects current trends in bacterial infections and resistance.

Conclusions:

  • A comprehensive strategy is needed to combat AMR, including robust R&D.
  • Continuous monitoring and evaluation of the antibacterial pipeline are crucial.
  • Targeted antibiotic development against priority pathogens is essential for global health security.

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