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Two new abietane diterpenoids from Caryopteris trichosphaera.

Qing-Yu Lu1, Zhao-Jie Wang1, Li-Yu Bai1

  • 1Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650500, People's Republic of China.

Fitoterapia
|October 25, 2024
PubMed
Summary

Two novel abietane diterpenoids were discovered from Caryopteris trichosphaera. One compound demonstrated antibacterial activity and synergistic effects with antibiotics against resistant bacteria.

Keywords:
AbietanesAntibacterial bioactivityCaryopteris trichosphaera

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Area of Science:

  • Natural Products Chemistry
  • Medicinal Chemistry
  • Pharmacognosy

Background:

  • Caryopteris trichosphaera is a plant source of bioactive compounds.
  • Abietane diterpenoids represent a class of natural products with diverse biological activities.
  • Antibiotic resistance in bacteria like MRSA and VRE is a significant global health concern.

Purpose of the Study:

  • To isolate and characterize new chemical constituents from Caryopteris trichosphaera.
  • To evaluate the antibacterial potential of isolated compounds.
  • To investigate synergistic effects of compounds with existing antibiotics.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation utilizing High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS) and Nuclear Magnetic Resonance (NMR) spectroscopy.
  • Antibacterial activity assays against Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococci (VRE).
  • Synergy testing with commercial antibiotics.

Main Results:

  • Two new abietane diterpenoids, named cartrisine A (1) and cartrisine B (2), were successfully isolated and identified.
  • Cartrisine B (2) exhibited moderate antibacterial activity against both MRSA and VRE.
  • Cartrisine B (2) demonstrated a significant synergistic effect when combined with market antibiotics against MRSA and VRE.

Conclusions:

  • Caryopteris trichosphaera is a source of novel abietane diterpenoids.
  • Cartrisine B shows promise as an antibacterial agent, particularly in combination therapy.
  • Further research into cartrisine B could lead to new strategies for combating antibiotic-resistant infections.