Functional potential of chitosan-metal nanostructures: Recent developments and applications

Chitosan (Cs), a naturally occurring biopolymer, has garnered significant interest due to its inherent biocompatibility, biodegradability, and minimal toxicity. This study investigates the effectiveness of various reaction strategies, including acylation, acetylation, and carboxymethylation, to enhance the solubility profile of Cs. This review provides a detailed examination of the rapidly developing field of Cs-based metal complexes and nanoparticles. It delves into the diverse synthesis methodologies employed for their fabrication, specifically focusing on ionic gelation and in-situ reduction techniques. Furthermore, the review offers a comprehensive analysis of the characterization techniques utilized to elucidate the physicochemical properties of these complexes. A range of analytical techniques are utilized, including Ultraviolet-Visible Spectroscopy (UV-Vis), Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and others. By comprehensively exploring a wide range of applications, the review emphasizes the significant potential of Cs in various scientific disciplines. Diagrams, figures, and tables effectively illustrate the synthesis processes, promoting a clear understanding for the reader. Chitosan-metal nanostructures/nanocomposites significantly enhance antimicrobial efficacy, drug delivery, and environmental remediation compared to standard chitosan composites. The integration of metal nanoparticles, such as silver or gold, improves chitosan's effectiveness against a range of pathogens, including resistant bacteria. These nanocomposites facilitate targeted drug delivery and controlled release, boosting therapeutic bioavailability. Additionally, they enhance chitosan's ability to absorb heavy metals and dyes from wastewater, making them effective for environmental applications. Overall, chitosan-metal nanocomposites leverage chitosan's biocompatibility while offering improved functionalities, making them promising materials for diverse applications. This paper sheds light on recent advancements in the applications of Cs metal complexes for various purposes, including cancer treatment, drug delivery enhancement, and the prevention of bacterial and fungal infections.