Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pattern of Agreement Among Medications Used During Pregnancy as Recorded in Self-Report and Administrative Claims From California.

Birth defects research·2026
Same author

Hull-Less Barley (<i>Hordeum vulgare</i> L. var. <i>nudum</i> Hook. f.): A Review of Its Phytochemistry, Bioactivities, Pharmacology and Applications.

Journal of agricultural and food chemistry·2026
Same author

Light-induced quantum friction of carbon nanotubes in water.

Nature·2026
Same author

Enantioselective effects of imazalil on banana postharvest ripening aroma revealed by integrated volatilomics, lipidomics and metabolomics.

Food chemistry: X·2026
Same author

The Efficacy and Safety of Platelet-Rich Plasma in the Treatment of Melasma: A Systematic Review and Meta-analysis.

Aesthetic plastic surgery·2026
Same author

A first-in-class bifunctional antibody targeting CD20 and CD37 remodels the immune microenvironment in relapsed or refractory B-cell malignancies.

Journal of hematology & oncology·2026

Related Experiment Video

Updated: Jun 9, 2025

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
07:08

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

8.3K

Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew.

Xiu-Peng Nie1,2, Xiao-Shan Xu1,2, Zhao Feng3,4

  • 1University of Chinese Academy of Sciences, Beijing 100049, China.

Eneuro
|October 25, 2024
PubMed
Summary

The Chinese tree shrew possesses a primate-like dorsolateral prefrontal cortex (dlPFC) with a distinct fourth layer. This finding suggests the tree shrew is a valuable model for studying dlPFC functions related to cognition.

Keywords:
dorsolateral prefrontal cortex (dlPFC)fourth layer (L4)granular cellmedial prefrontal cortex (mPFC)mediodorsal nucleus (MD)orbital frontal cortex (OFC)primatetree shrew

More Related Videos

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset
04:43

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset

Published on: February 1, 2019

9.6K
2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

3.8K

Related Experiment Videos

Last Updated: Jun 9, 2025

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
07:08

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

8.3K
Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset
04:43

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset

Published on: February 1, 2019

9.6K
2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

3.8K

Area of Science:

  • Neuroscience
  • Comparative Anatomy
  • Primate Evolution

Background:

  • The Chinese tree shrew is considered the closest living relative to primates.
  • It is unknown if the tree shrew's dorsolateral prefrontal cortex (dlPFC) is comparable to that of primates.
  • Primate dlPFC is characterized by a fourth layer (L4) and connections with the mediodorsal nucleus (MD).

Purpose of the Study:

  • To investigate the structural and connectional characteristics of the tree shrew's dlPFC.
  • To determine if the tree shrew dlPFC exhibits primate-like features, specifically L4 and MD connectivity.
  • To assess the potential of the tree shrew as a model organism for studying dlPFC functions.

Main Methods:

  • Adeno-associated virus (AAV)-mediated gene expression in mediodorsal nucleus (MD) neurons.
  • Fluorescence micro-optical sectioning tomography to trace projection pathways.
  • Cre-dependent transsynaptic viral tracing to identify specific neuronal connections.
  • Cytoarchitectural analysis using Nissl, Golgi, and vGlut2 staining to confirm cellular structures.

Main Results:

  • MD neurons project to the dlPFC, hippocampus, and corpus striatum in tree shrews.
  • Transsynaptic tracing revealed MD projections targeting the L4 of the dlPFC.
  • Cytoarchitectural studies confirmed the presence of granular cells in dlPFC L4 and reciprocal connections between dlPFC L5/6 and the MD.

Conclusions:

  • The Chinese tree shrew exhibits a primate-like dlPFC, characterized by L4 and reciprocal MD connections.
  • These findings support the use of the tree shrew as a model for studying cognition-related dlPFC functions.
  • The study provides crucial insights into the evolution of the prefrontal cortex in primates and their relatives.