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Optimizing chemically stable chloramphenicol in-situ gel formulations using poloxamer 407 and HPMC through
Insan Sunan Kurniawansyah1, Taofik Rusdiana2, Insi Farisa Desy Arya3
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia. insan.sunan.kurniawansyah@unpad.ac.id.
Abstract:
The primary goal was to enhance the stability and bioavailability of chloramphenicol for ophthalmic use without compromising patient comfort, such as causing blurry vision. This study employed a 2-level full factorial design to optimize the formulation, exploring different concentrations of poloxamer 407 and HPMC to achieve this objective.
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