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Related Concept Videos

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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Adipose Tissue Plasticity: A Comprehensive Definition and Multidimensional Insight.

Yu-Yao Mo1, Yu-Xin Han1, Shi-Na Xu1

  • 1National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, China.

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|October 26, 2024
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Adipose tissue plasticity, the dynamic remodeling of fat tissue, plays a key role in obesity and homeostasis. Understanding this adaptability offers new strategies for treating metabolic diseases.

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Area of Science:

  • Metabolic research
  • Physiology
  • Cell biology

Background:

  • Adipose tissue comprises adipocytes, immune cells, nerves, and extracellular matrix.
  • It dynamically adapts to physiological and pathological stresses through cellular and lipid content changes, termed adipose tissue plasticity.
  • This plasticity is crucial for growth, obesity, organismal protection, and maintaining internal environmental homeostasis.

Purpose of the Study:

  • To comprehensively define adipose tissue plasticity.
  • To elucidate the relationship between adipose tissue plasticity and disease development.
  • To explore therapeutic strategies for obesity targeting adipose tissue plasticity.

Main Methods:

  • Literature review and synthesis of existing research on adipose tissue plasticity.
  • Analysis of cellular and molecular mechanisms underlying adipose tissue adaptation.
  • Review of current and potential therapeutic interventions for obesity related to adipose tissue plasticity.

Main Results:

  • Adipose tissue plasticity involves alterations in adipocyte size, number, lipid storage, and differentiation.
  • It also includes changes in tissue distribution and cellular composition.
  • Individual differences in plasticity thresholds exist, impacting disease susceptibility.

Conclusions:

  • Adipose tissue plasticity is a fundamental adaptive mechanism with significant implications for health and disease.
  • Understanding its nuances provides novel insights into obesity and related metabolic disorders.
  • Targeting adipose tissue plasticity presents promising avenues for developing effective obesity treatments.