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Postoperative Electroacupuncture Boosts Cognitive Function Recovery after Laparotomy in Mice.

Yuen-Shan Ho¹, Wai-Yin Cheng^2,3,4, Michael Siu-Lun Lai¹

¹School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China.

|October 26, 2024

Summary

Electroacupuncture (EA) mitigates prolonged cognitive deficits after surgery by reducing neuroinflammation and tau pathology. This non-pharmacological approach offers a potential treatment for postoperative cognitive dysfunction (POCD).

Keywords:

Chinese medicine acupuncture cognition inflammation memory surgery tau

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Area of Science:

Neuroscience
Pharmacology
Gerontology

Background:

Postoperative cognitive dysfunction (POCD) is a prevalent complication impacting memory and executive functions.
Neuroinflammation and Alzheimer's disease (AD) pathology are key contributors to POCD.
Acupuncture shows promise for early-stage POCD, but long-term effects remain unclear.

Purpose of the Study:

To investigate the long-term effects of electroacupuncture (EA) on cognitive impairment and neuroinflammation following laparotomy in mice.
To explore the molecular mechanisms underlying EA's protective effects against POCD.

Main Methods:

Mice underwent laparotomy followed by daily electroacupuncture (EA) for two weeks.
Cognitive functions (memory, executive function) were assessed.
Molecular analyses examined tau phosphorylation, kinase activation, and glial responses.

Main Results:

Laparotomy induced sustained memory and executive function impairments.
Postoperative EA treatment significantly mitigated these cognitive deficits.
EA reduced tau phosphorylation and suppressed tau-related kinases and glial activation, comparable to ibuprofen.
EA demonstrated neuroprotective effects by suppressing neuroinflammation.

Conclusions:

Electroacupuncture (EA) provides long-term benefits for cognitive dysfunction following surgery.
EA's anti-inflammatory effects contribute to its protective role in a mouse model of POCD.
EA presents a promising non-pharmacological intervention for managing POCD.