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Candidate Molecular Biomarkers of Traumatic Brain Injury: A Systematic Review
Tatiana V Butkova1, Kristina A Malsagova1, Valeriya I Nakhod1
1Institute of Biomedical Chemistry, 109028 Moscow, Russia.
Biomolecules
|October 26, 2024
Summary
Objective markers are crucial for diagnosing traumatic brain injury (TBI) severity. Blood-based proteins and metabolites can indicate TBI progression and aid in developing effective treatments.
Area of Science:
- Neuroscience
- Biochemistry
- Trauma Care
Background:
- Traumatic brain injury (TBI) is a major cause of death and disability.
- Effective TBI management requires timely diagnosis and prevention of secondary injury.
- Objective injury severity markers are needed.
Purpose of the Study:
- To explore molecular factors in blood as objective markers for TBI severity.
- To understand the dual-directional substance flow across the disrupted blood-brain barrier in TBI.
- To identify key signaling pathways regulating TBI-induced damage and repair.
Main Methods:
- Analysis of molecular factors (proteins, metabolites) in blood post-trauma.
- Investigation of blood-brain barrier permeability changes.
- Study of immune cell infiltration and serological protein movement.
Main Results:
- Blood contains proteins and metabolites indicative of TBI severity.
- TBI involves bidirectional substance flow: brain-to-blood and blood-to-brain.
- These flows exacerbate secondary brain damage.
Conclusions:
- Molecular markers in blood show promise for TBI assessment.
- Understanding bidirectional flows is key to mitigating secondary injury.
- Targeting signaling events may improve TBI treatment outcomes.
