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Antihypertensive Drugs: Vasodilators01:23

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Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
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Bioluminescence Imaging of NADPH Oxidase Activity in Different Animal Models
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Targeting NADPH Oxidase as an Approach for Diabetic Bladder Dysfunction.

Tammyris Helena Rebecchi Silveira1, Fábio Henrique Silva1, Warren G Hill2

  • 1Laboratory of Pharmacology, São Francisco University (USF), Bragança Paulista, Sao Paulo 12916-900, Brazil.

Antioxidants (Basel, Switzerland)
|October 26, 2024
PubMed
Summary

Diabetic bladder dysfunction (DBD) affects over half of diabetes mellitus (DM) patients. This review explores how NADPH oxidase (NOX) enzymes contribute to DBD, suggesting NOX as a potential therapeutic target.

Keywords:
NADPH oxidaseincontinencemicturitionredox signalingurinary bladderurology

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Area of Science:

  • Urology
  • Endocrinology
  • Biochemistry

Background:

  • Diabetic bladder dysfunction (DBD) is a common complication of diabetes mellitus (DM), impacting over 50% of patients.
  • Current treatments for DBD are limited, with progressive bladder dysfunction leading to incontinence.
  • DM-induced tissue damage is linked to altered redox signaling, a mechanism implicated in other diabetic complications.

Purpose of the Study:

  • To review the roles of NADPH oxidase (NOX) isoforms in normal bladder function.
  • To investigate the impact of NOX on the pathogenesis of diabetic bladder dysfunction (DBD).
  • To highlight the potential of NOX as a therapeutic target for DBD.

Main Methods:

  • Literature review of studies on NOX isoforms and their functions.
  • Analysis of existing research on redox signaling in diabetic complications.
  • Synthesis of evidence linking NOX activity to bladder dysfunction in diabetes.

Main Results:

  • NADPH oxidase (NOX) enzymes are central to reactive oxygen species (ROS) production.
  • NOX plays a significant role in other diabetic complications affecting organs like eyes, kidneys, heart, and nerves.
  • A gap exists in understanding NOX's specific role in bladder function and DBD.

Conclusions:

  • Further investigation into NOX's role in DBD pathogenesis is crucial.
  • NOX may act as a trigger or effector in DBD.
  • Targeting NOX could offer a novel therapeutic strategy for diabetic bladder dysfunction.