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Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel
Nayra Merino de Paz1, Marta Carrillo-Palau2, Alejandro Hernández-Camba3
1Division of Dermatology, Dermamedicin Clínicas, 38004 Santa Cruz de Tenerife, Spain.
Abstract:
Malondialdehyde (MDA) is a naturally occurring organic compound produced as a byproduct of lipid peroxidation. It serves as one of the most widely recognized biomarkers for oxidative stress. Elevated levels of MDA have been observed in patients with inflammatory bowel disease (IBD), suggesting its involvement in the pathogenesis and progression of the disease. In this study, we analyzed MDA levels within a well-characterized and extensive cohort of IBD patients. Our objective was to investigate the association between MDA levels and disease characteristics in this population. This is a cross-sectional study that encompassed 197 patients with IBD. Multivariable linear regression analysis was performed to study the relationship between disease characteristics and circulating MDA. MDA was significantly associated with male sex in IBD patients but not with other demographic characteristics or classic cardiovascular risk factors. Regarding disease features such as phenotype or activity indices, their relationship with MDA was scarce. Several lipid profile molecules showed a significant association with MDA levels after multivariable analysis. Similarly, the liver fibrosis-4 index and hepatic elastography values were significantly related to higher MDA levels after adjusting for covariates. In conclusion, the sources of elevated MDA in IBD are primarily linked to lipid profile abnormalities and liver disease.
Insights
Malondialdehyde (MDA), a marker of oxidative stress, is elevated in inflammatory bowel disease (IBD). This study found MDA levels in IBD patients are linked to lipid profiles and liver disease, not disease activity.
Area of Science:
- Biochemistry
- Clinical Medicine
- Gastroenterology
Background:
- Malondialdehyde (MDA) is a biomarker for oxidative stress, with elevated levels observed in inflammatory bowel disease (IBD).
- Understanding the factors contributing to MDA elevation in IBD is crucial for disease management.
Purpose of the Study:
- To investigate the association between circulating Malondialdehyde (MDA) levels and disease characteristics in a cohort of 197 IBD patients.
Main Methods:
- Cross-sectional study design.
- Multivariable linear regression analysis to assess relationships between MDA and demographic/clinical factors.
- Analysis included lipid profiles, liver fibrosis-4 index, and hepatic elastography.
Main Results:
- MDA levels were significantly associated with male sex in IBD patients.
- No significant association was found between MDA and other demographic factors or disease activity indices.
- Elevated MDA showed significant associations with specific lipid profile molecules, liver fibrosis-4 index, and hepatic elastography values.
Conclusions:
- In IBD patients, elevated Malondialdehyde (MDA) is primarily associated with lipid profile abnormalities and liver disease.
- These findings suggest that lipid metabolism and liver health are key factors influencing oxidative stress markers in IBD.
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