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Nitric Oxide Signaling and Sensing in Age-Related Diseases
Olga Mazuryk1, Ilona Gurgul1, Maria Oszajca1
1Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland.
Antioxidants (Basel, Switzerland)
|October 26, 2024
Summary
Nitric oxide (NO) plays a complex role in aging, impacting cardiovascular, nervous, and immune systems. Understanding NO
Area of Science:
- Biochemistry
- Physiology
- Pathology
Background:
- Nitric oxide (NO) is a critical signaling molecule in human physiology.
- NO is implicated in various physiological and pathological processes.
- Dysregulation of NO signaling contributes to age-related diseases.
Purpose of the Study:
- To review the role of nitric oxide (NO) in age-related diseases.
- To explore NO's mechanisms in cardiovascular, nervous, and immune systems.
- To analyze therapeutic strategies targeting NO signaling.
Main Methods:
- Literature review focusing on NO's role in aging.
- Analysis of NO signaling pathways and post-translational modifications (S-nitrosation, nitration).
- Examination of therapeutic interventions and diagnostic methods for NO derivatives.
Main Results:
- NO exhibits dual protective and detrimental effects in aging, dependent on context.
- NO signaling is altered in age-related cardiovascular, neurological, and immune dysfunction.
- Post-translational modifications significantly influence NO's biological activity.
Conclusions:
- NO's complex, context-dependent role in aging necessitates nuanced therapeutic approaches.
- Modulating NO signaling offers potential for treating age-related diseases.
- Further research is needed to refine NO-based diagnostics and therapies.
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