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Innovations in Nuclear Medicine Imaging for Reactive Oxygen Species: Applications and Radiopharmaceuticals
Joo Yeon Park1, Sun Mi Park1, Tae Sup Lee2
1Department of Nuclear Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea.
Antioxidants (Basel, Switzerland)
|October 26, 2024
Summary
Nuclear medicine imaging can detect reactive oxygen species (ROS), crucial for understanding diseases. This review covers radiopharmaceuticals and biomarkers for ROS detection in vivo.
Area of Science:
- Biomedical Imaging
- Molecular Imaging
- Radiochemistry
Background:
- Reactive oxygen species (ROS) are vital for cellular function but excessive levels cause cellular damage and disease.
- Elevated ROS is implicated in cardiovascular, inflammatory, and neurodegenerative disorders.
Purpose of the Study:
- To review nuclear medicine imaging techniques for detecting reactive oxygen species (ROS).
- To evaluate radiopharmaceuticals and biomarkers for in vivo ROS detection.
Main Methods:
- Comprehensive literature search of PubMed.
- Review of radiopharmaceuticals targeting ROS, including vitamin C analogs and fluorescent probe analogs.
- Examination of biomarkers such as mitochondrial complex I and cystine/glutamate transporter.
Main Results:
- Nuclear medicine techniques like PET and SPECT enable in vivo identification of ROS biomarkers.
- Various radiopharmaceuticals show potential for ROS detection.
- Specific biomarkers targeting cellular pathways involved in ROS production and management were identified.
Conclusions:
- Nuclear medicine imaging offers a promising avenue for diagnosing ROS-related pathologies.
- Further development of targeted radiopharmaceuticals is essential for advancing ROS detection.
- This review highlights key radiopharmaceuticals and biomarkers for future research in ROS imaging.
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