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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Differences in Breast Cancer Subtypes among Racial/Ethnic Groups.

Tamlyn Sasaki1, Akash Liyanage1, Surbhi Bansil1

  • 1John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI 96813, USA.

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|October 26, 2024
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Summary

Native Hawaiian women show lower rates of triple-negative breast cancer, suggesting racial/ethnic differences in breast cancer subtypes may impact prognosis and outcomes.

Keywords:
Hawaiibreast cancerdisparitiesracesubtype

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Area of Science:

  • Oncology
  • Epidemiology
  • Health Disparities

Background:

  • Breast cancer prognosis disparities are linked to subtype incidence variations across racial/ethnic groups.
  • This study investigates racial/ethnic breast cancer subtype differences in Hawai'i to understand contributing factors to observed disparities.

Purpose of the Study:

  • To determine if race/ethnicity correlates with specific breast cancer subtypes in Hawai'i.
  • To explore potential links between these subtype differences and breast cancer outcome disparities.

Main Methods:

  • Analysis of 4591 breast cancer cases diagnosed between 2015-2022 from two Hawai'i tumor registries.
  • Evaluation of cases based on age, race, breast cancer subtype (ER, PR, HER2), histology, county, and year.

Main Results:

  • Native Hawaiian women, both premenopausal and postmenopausal, had a significantly lower likelihood of being diagnosed with triple-negative breast cancer.
  • Specific odds ratios (OR) and confidence intervals (CI) were reported for these findings (e.g., OR=0.26, 95% CI 0.12-0.58 for premenopausal women).

Conclusions:

  • The study confirms racial/ethnic variations in breast cancer subtypes within the studied population.
  • These subtype differences may contribute to disparities in breast cancer outcomes.
  • Further research into clinical and pathological features is recommended to better understand outcome disparities.