Related Experiment Video
Updated: Jun 9, 2025
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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
8.0K
Differences in Breast Cancer Subtypes among Racial/Ethnic Groups
Tamlyn Sasaki1, Akash Liyanage1, Surbhi Bansil1
1John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI 96813, USA.
Cancers
|October 26, 2024
Summary
Native Hawaiian women show lower rates of triple-negative breast cancer, suggesting racial/ethnic differences in breast cancer subtypes may impact prognosis and outcomes.
Area of Science:
- Oncology
- Epidemiology
- Health Disparities
Background:
- Breast cancer prognosis disparities are linked to subtype incidence variations across racial/ethnic groups.
- This study investigates racial/ethnic breast cancer subtype differences in Hawai'i to understand contributing factors to observed disparities.
Purpose of the Study:
- To determine if race/ethnicity correlates with specific breast cancer subtypes in Hawai'i.
- To explore potential links between these subtype differences and breast cancer outcome disparities.
Main Methods:
- Analysis of 4591 breast cancer cases diagnosed between 2015-2022 from two Hawai'i tumor registries.
- Evaluation of cases based on age, race, breast cancer subtype (ER, PR, HER2), histology, county, and year.
Main Results:
- Native Hawaiian women, both premenopausal and postmenopausal, had a significantly lower likelihood of being diagnosed with triple-negative breast cancer.
- Specific odds ratios (OR) and confidence intervals (CI) were reported for these findings (e.g., OR=0.26, 95% CI 0.12-0.58 for premenopausal women).
Conclusions:
- The study confirms racial/ethnic variations in breast cancer subtypes within the studied population.
- These subtype differences may contribute to disparities in breast cancer outcomes.
- Further research into clinical and pathological features is recommended to better understand outcome disparities.
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