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Dietary Rhythms and MASLD-Related Hepatocellular Carcinoma.

Nadia Malakmahmoudi¹, Roberta Pisu¹, Ezio Laconi¹

¹Department of Biomedical Science, University of Cagliari, 09124 Cagliari, Italy.

|October 26, 2024

Summary

Adequate fasting intervals between meals may benefit health, particularly in managing metabolic dysfunction-associated steatotic liver disease (MASLD) and reducing hepatocellular carcinoma (HCC) risk. This study proposes a hypothesis linking time-restricted eating to food quantity and quality.

Keywords:

HCC MASLD fasting steatosis time-restricted feeding/eating

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Area of Science:

Nutrition science
Gastroenterology
Chronic disease management

Background:

Dietary rhythms are increasingly recognized for their impact on overall health.
Fasting intervals between meals show potential benefits for age-related chronic diseases.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly linked to diet, with diet-based strategies crucial for managing its progression, including hepatocellular carcinoma (HCC).

Purpose of the Study:

To review evidence connecting fasting intervals, MASLD, and HCC.
To propose a hypothesis explaining the beneficial effects of time-restricted eating (TRE).
To offer a testable framework for understanding TRE's impact on MASLD and HCC.

Main Methods:

Literature review of experimental and epidemiological studies.
Synthesis of current evidence on dietary rhythms, MASLD, and HCC.
Formulation of a working hypothesis based on existing data.

Main Results:

Evidence suggests a link between adequate fasting periods and improved health outcomes.
MASLD and HCC progression are influenced by dietary patterns and eating schedules.
Conflicting results in the literature may be reconciled by considering food quantity and quality within TRE.

Conclusions:

Time-restricted eating schedules may offer benefits for MASLD and HCC.
The hypothesis posits that food quantity and quality are key mediators of TRE's effects.
Further research is needed to test this hypothesis and refine dietary recommendations.