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Proton Therapy in Uveal Melanoma.
Adrian Wai Chan1, Haibo Lin2,3, Irini Yacoub2
1Department of Radiation Oncology, Sunnybrook Health Sciences Centre, The University of Toronto, Toronto, ON M4N 3M5, Canada.
Cancers
|October 26, 2024
Summary
Proton therapy is an effective treatment for uveal melanoma, offering advantages for larger tumors and those near critical structures. This approach enhances tumor control and minimizes side effects compared to traditional methods.
Area of Science:
- Ophthalmology
- Radiation Oncology
- Medical Physics
Background:
- Uveal melanoma is the most common primary intraocular malignancy in adults.
- Current treatments for localized disease include enucleation, brachytherapy, and proton beam therapy.
Purpose of the Study:
- To evaluate the role of proton therapy in definitive uveal melanoma management.
- Focus on physics, radiobiology, treatment techniques, and outcomes.
Main Methods:
- Narrative review of current literature on proton therapy for uveal melanoma.
- Emphasis on case selection, treatment efficacy, and side effects.
Main Results:
- Proton therapy offers advantages for thicker uveal melanomas (>8 mm) due to precise dose fall-off, protecting the retina and optic nerve.
- Potential benefits in tumor control for radioresistant ocular melanomas due to increased relative biological effectiveness.
- Valuable for tumors near the optic nerve, reducing visual toxicities compared to brachytherapy.
Conclusions:
- Proton therapy is an effective treatment for uveal melanoma.
- Offers advantages over brachytherapy for large tumors and those adjacent to the optic nerve or extra-ocular muscle insertions.
