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Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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HIPEC as Up-Front Treatment in Locally Advanced Ovarian Cancer.

Michail Karanikas¹, Konstantinia Kofina¹, Dimitrios Kyziridis²

¹1st Department of Surgery, School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

|October 26, 2024

Summary

Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with cytoreductive surgery (CRS) significantly improves survival rates for women with advanced ovarian cancer. This combined treatment reduces mortality and recurrence risk compared to CRS alone.

Keywords:

HIPEC cytoreductive surgery ovarian cancer survival

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Area of Science:

Gynecologic Oncology
Surgical Oncology
Chemotherapy

Background:

Ovarian cancer is a leading cause of gynecologic cancer mortality.
Optimal treatment for advanced ovarian cancer often involves cytoreductive surgery (CRS).
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a regional chemotherapy delivery method.

Purpose of the Study:

To evaluate the impact of HIPEC combined with CRS on survival outcomes in treatment-naïve advanced ovarian cancer patients.
To identify prognostic factors influencing survival and recurrence in this patient population.

Main Methods:

Retrospective analysis comparing patients who underwent CRS plus HIPEC versus CRS alone.
Clinicopathologic variables were analyzed for correlation with overall survival, disease-specific survival, and disease-free survival.
Statistical methods included Kaplan-Meier analysis and multivariate Cox proportional hazards regression.

Main Results:

Patients receiving CRS plus HIPEC demonstrated significantly higher 5- and 10-year overall, disease-specific, and disease-free survival rates.
HIPEC significantly reduced the risk of death from any cause (aHR=0.33), cancer-specific death (aHR=0.25), and recurrence (aHR=0.54).
Independent prognostic indicators for poor survival included poor performance status, serous carcinoma, and morbidity; degree of differentiation predicted disease-specific survival; extent of carcinomatosis predicted disease-free survival.

Conclusions:

The addition of HIPEC to CRS offers improved survival benefits for treatment-naïve advanced ovarian cancer patients.
HIPEC is a valuable therapeutic option for selected patients undergoing cytoreductive surgery.
Further research into prognostic indicators can refine patient selection and treatment strategies.