RNA Binding Proteins as Potential Therapeutic Targets in Colorectal Cancer

Area of Science:

• Molecular Biology
• Oncology
• Gene Regulation

Background:

• RNA-binding proteins (RBPs) regulate gene expression post-transcriptionally, impacting mRNA splicing, stability, and translation.
• While RBPs maintain intestinal homeostasis, their dysregulation is implicated in colorectal cancer (CRC) development and progression.

Purpose of the Study:

• To review the critical roles of specific RBPs (LIN28, IGF2BP1-3, Musashi, HuR, CELF1) in CRC.
• To explore the therapeutic potential of targeting RBPs in CRC treatment.

Main Methods:

• Literature review focusing on RBP functions in CRC.
• Analysis of small molecule inhibitors targeting key RBPs.

Main Results:

• Specific RBPs (LIN28, IGF2BP1-3, Musashi, HuR, CELF1) regulate oncogenes and tumor suppressors in CRC by modulating mRNA stability and translation.
• Small molecule inhibitors targeting these RBPs have demonstrated promising preclinical efficacy.

Conclusions:

• RBPs represent significant therapeutic targets for colorectal cancer.
• Development of selective and potent RBP inhibitors offers a novel treatment strategy for CRC, despite existing challenges.