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Activation of Nrf2 and FXR via Natural Compounds in Liver Inflammatory Disease

Marta Belka1,2, Aleksandra Gostyńska-Stawna3, Maciej Stawny3

  • 1Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.

International Journal of Molecular Sciences
|October 26, 2024
PubMed

Insights

Natural compounds targeting the farnesoid X receptor (FXR) and nuclear factor erythroid 2-related factor 2 (Nrf2) pathways show promise for treating liver inflammation and oxidative stress. These FXR agonists may offer new therapeutic strategies for liver diseases.

Area of Science:

  • Hepatology
  • Molecular Biology
  • Pharmacology

Background:

  • Liver inflammation is associated with oxidative stress and altered bile acid/fatty acid metabolism.
  • The farnesoid X receptor (FXR) regulates bile acid homeostasis, while nuclear factor erythroid 2-related factor 2 (Nrf2) combats oxidative stress.
  • Dysregulation of these pathways contributes to liver pathology.

Purpose of the Study:

  • To review the interplay between FXR and Nrf2 in liver inflammatory diseases.
  • To explore the therapeutic potential of natural FXR agonists in modulating these pathways.
  • To discuss mechanisms and experimental models of liver inflammation.

Main Methods:

  • Literature review focusing on the molecular mechanisms of liver inflammation.
  • Analysis of natural compounds (e.g., resveratrol, curcumin) that target FXR and Nrf2.
  • Examination of experimental models for liver diseases like MAFLD and viral hepatitis.

Main Results:

  • Several natural compounds demonstrate the ability to modulate both FXR and Nrf2 pathways.
  • These compounds show potential in alleviating liver inflammation, oxidative stress, and damage.
  • The review identifies specific compounds with therapeutic promise for various liver conditions.

Conclusions:

  • Targeting both Nrf2 and FXR pathways with natural compounds offers a promising therapeutic avenue for liver diseases.
  • Further research and clinical studies are needed to validate these findings and overcome limitations.
  • Natural FXR agonists represent a potential strategy for managing liver inflammation and associated pathologies.
Keywords:
FXRMAFLDNrf2liver inflammation

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