Related Experiment Video

Updated: Jun 9, 2025

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
10:56

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

68.4K

Reciprocal Dynamics of Metabolism and mRNA Translation in Tumor Angiogenesis

Jacopo Lidonnici1, Roxana E Oberkersch2

  • 1Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova, 35128 Padova, Italy.

International Journal of Molecular Sciences
|October 26, 2024
PubMed

Insights

Targeting endothelial cell metabolism offers a new strategy against tumor angiogenesis, as it influences blood vessel formation. Understanding how cell metabolism impacts mRNA translation could lead to better cancer therapies.

Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Angiogenesis is crucial for tumor growth and metastasis.
  • Current anti-angiogenic therapies targeting vascular endothelial growth factor (VEGF) have limited efficacy due to compensatory mechanisms.
  • Endothelial cell metabolism is emerging as a key regulator of tumor angiogenesis.

Purpose of the Study:

  • To review the current understanding of the relationship between endothelial cell metabolism and mRNA translation in angiogenesis.
  • To explore how metabolic pathways influence mRNA translation during blood vessel formation.
  • To identify potential therapeutic targets within endothelial cell metabolism for anti-angiogenic strategies.

Main Methods:

  • Literature review of recent studies on endothelial cell metabolism and mRNA translation in angiogenesis.
  • Analysis of mechanisms linking metabolic processes to translational control in endothelial cells.
  • Synthesis of evidence for therapeutic potential.

Main Results:

  • Metabolic pathways significantly influence mRNA translation in endothelial cells during angiogenesis.
  • Specific metabolic regulators can be targeted to modulate blood vessel formation.
  • The interplay between metabolism and translation offers novel therapeutic avenues.

Conclusions:

  • Targeting endothelial cell metabolism presents a promising strategy to overcome limitations of current anti-angiogenic therapies.
  • Further research into the metabolic control of mRNA translation in angiogenesis could yield innovative treatments for cancer and other diseases.
Keywords:
endothelial cell metabolismmRNA translationtumor vasculature

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants07:39

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

34
Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis09:42

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

8.8K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Regulated mRNA Transport02:22

Regulated mRNA Transport

In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
6.2K