Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic osteomyelitis: bone and gallium scan patterns associated with active disease.

S S Tumeh, P Aliabadi, B N Weissman

    Radiology
    |March 1, 1986
    PubMed
    Summary

    Gallium scans can help diagnose osteomyelitis in patients with prior bone disease. However, only one specific scan pattern reliably indicates active infection, while others offer limited diagnostic value.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prevalence of intra-articular mineralization on knee computed tomography: the multicenter osteoarthritis study.

    Osteoarthritis and cartilage·2023
    Same author

    Evidence that meniscus damage may be a component of osteoarthritis: the Framingham study.

    Osteoarthritis and cartilage·2015
    Same author

    Pre-radiographic osteoarthritic changes are highly prevalent in the medial patella and medial posterior femur in older persons: Framingham OA study.

    Osteoarthritis and cartilage·2013
    Same author

    Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI.

    Osteoarthritis and cartilage·2013
    Same author

    Pre-radiographic MRI findings are associated with onset of knee symptoms: the most study.

    Osteoarthritis and cartilage·2009
    Same author

    Is obesity a risk factor for progressive radiographic knee osteoarthritis?

    Arthritis and rheumatism·2009

    Area of Science:

    • Nuclear Medicine
    • Radiology
    • Infectious Disease

    Background:

    • Bone and gallium scans are diagnostic tools for osteomyelitis, particularly in patients with pre-existing bone conditions.
    • Interpreting these scans can be challenging due to confounding factors in patients with prior bone disease.

    Purpose of the Study:

    • To refine the interpretation criteria for bone and gallium scans in patients with clinically suspected osteomyelitis.
    • To evaluate the diagnostic accuracy of different scintigraphic patterns for active osteomyelitis.

    Main Methods:

    • Retrospective review of 136 consecutive patients with suspected osteomyelitis.
    • Analysis of five distinct scintigraphic patterns observed on bone and gallium scans.
    • Calculation of true-positive, false-positive ratios, likelihood ratios, and posterior probabilities for each pattern.

    Related Experiment Videos

    Main Results:

    • Only one scintigraphic pattern, where gallium uptake surpasses bone-seeking radiopharmaceutical uptake, was found to be indicative of active osteomyelitis.
    • Other observed patterns demonstrated minimal impact, slightly increasing or decreasing the probability of active disease.
    • The degree of probability change was influenced by the pre-test probability of disease, derived from clinical and laboratory data.

    Conclusions:

    • Gallium scan interpretation in osteomyelitis requires careful consideration of specific patterns, especially in patients with prior bone disease.
    • A single scintigraphic pattern shows significant diagnostic utility, while others have limited predictive value.
    • Integrating scintigraphic findings with clinical assessment is crucial for accurate osteomyelitis diagnosis.