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Chronic Kidney Disease Progression-A Challenge

Silvio Maringhini1, Carmine Zoccali2,3,4

  • 1Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), 90127 Palermo, Italy.

Biomedicines
|October 26, 2024
PubMed

Insights

Chronic kidney disease (CKD) progression involves declining renal function, often due to glomerular damage. Understanding risk factors and biomarkers is key to developing interventions that slow disease progression.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Biomarker Research

Background:

  • Chronic kidney disease (CKD) is a progressive decline in renal function.
  • Glomerular damage via hyperfiltration is a leading hypothesis for CKD progression.
  • Accurate measurement of renal function, primarily glomerular filtration rate (GFR), is vital for CKD management.

Purpose of the Study:

  • To review recent publications on chronic kidney disease progression.
  • To highlight potential future research directions in CKD.
  • To discuss GFR measurement, progression mechanisms, biomarkers, risk factors, and therapeutic strategies.

Main Methods:

  • Literature review of recent publications on CKD progression.
  • Analysis of GFR measurement evolution and CKD progression mechanisms.
  • Synthesis of findings on biomarkers, risk factors, and therapeutic interventions.

Main Results:

  • Identified various factors accelerating CKD progression, some modifiable.
  • Highlighted available drugs and dietary modifications to slow CKD progression.
  • Discussed the evolution of GFR measurement and current understanding of progression mechanisms.

Conclusions:

  • Understanding CKD progression mechanisms is crucial for effective therapeutic strategies.
  • Interventions including pharmacological and dietary approaches can slow CKD progression.
  • Further research is needed to refine GFR measurement and identify novel therapeutic targets.

Keywords:
CKD progressioncardiovascular complicationschronic kidney disease (CKD)end-stage kidney disease (ESKD)

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