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Updated: Jul 1, 2026

Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging
Published on: April 27, 2014
Cognitive Effects of Transcranial Direct Current Stimulation Plus Robotic Verticalization in Minimally Conscious
Antonio Gangemi1, Rosaria De Luca1, Rosa Angela Fabio2
1IRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, C.da Casazza, 98124 Messina, Italy.
Combining transcranial direct current stimulation (tDCS) with robotic verticalization training (RVT) significantly improved cognitive function and P300 latency in patients with disorders of consciousness (DoCs). This integrated approach shows promise for enhancing recovery in minimally conscious state (MCS).
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Clinical Neurophysiology
Background:
- Disorders of Consciousness (DoCs) present significant challenges in neurorehabilitation.
- Transcranial direct current stimulation (tDCS) modulates cortical excitability and is explored for DoC treatment.
- Robotic verticalization training (RVT) aids motor and cognitive recovery.
Purpose of the Study:
- To evaluate the combined effects of tDCS and RVT in individuals with DoCs.
- To assess the efficacy of this integrated approach compared to RVT alone.
Main Methods:
- A quasi-randomized study involving 24 subjects with chronic minimally conscious state (MCS).
- Participants received either RVT alone (control group) or combined tDCS and RVT (experimental group).
- Treatments were administered five times weekly for four weeks, with tDCS applied over the dorsolateral prefrontal cortex (DLPFC).
Main Results:
- The experimental group showed greater improvements in cognitive functioning compared to the control group.
- Significant enhancements in P300 latency were observed in the combined tDCS and RVT group.
- The combination therapy demonstrated superior outcomes over RVT alone.
Conclusions:
- The integrated approach of tDCS with RVT offers significant benefits for patients with MCS.
- This combination therapy has the potential to enhance cognitive recovery, including reducing P300 latency.
- This study highlights a promising therapeutic strategy for improving outcomes in disorders of consciousness.
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