Related Experiment Video

Updated: Jun 9, 2025

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

202

Hypertension-Induced Biomechanical Modifications in the Aortic Wall and Their Role in Stanford Type B Aortic

Yuhao Wei1,2, Da Li3, Chengxin Weng4

  • 1Department of Mechanics & Engineering, College of Architecture & Environment, Sichuan University, Chengdu 610065, China.

Biomedicines
|October 26, 2024
PubMed

Insights

Unstable hypertension significantly damages aortic biomechanical properties more than stable hypertension, increasing type B aortic dissection (TBAD) risk. Consistent blood pressure management is crucial for hypertensive patients to mitigate TBAD development.

Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Aortic Disease

Background:

  • Hypertension is a primary risk factor for type B aortic dissection (TBAD).
  • Inconsistent hypertension management leads to stable or unstable blood pressure states.
  • The biomechanical impact of stable versus unstable hypertension on the aorta is not well understood.

Purpose of the Study:

  • To investigate the effects of stable and unstable hypertension on aortic biomechanical properties.
  • To identify which blood pressure state poses a greater risk for TBAD development.

Main Methods:

  • Fatigue tensile tests were performed on 183 aortic samples (axial and circumferential).
  • Samples were grouped under normotension, stable hypertension, and unstable hypertension conditions.
  • Evaluated biomechanical properties included elastic modulus, energy loss, and peeling force.

Main Results:

  • Both stable and unstable hypertension decreased elastic modulus and altered collagen fiber content.
  • Unstable hypertension resulted in the highest energy loss.
  • Peeling force was significantly reduced under both hypertension states, more so under unstable hypertension.

Conclusions:

  • Stable and unstable hypertension significantly impair aortic wall biomechanics.
  • Unstable hypertension causes greater biomechanical damage to the aorta compared to stable hypertension.
  • Strict blood pressure control is recommended for hypertensive patients to reduce TBAD risk.
Abstract

Keywords:
Stanford type B aortic dissectionbiomechanical propertyblood pressure managementstable hypertensionunstable hypertension

More Related Videos

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy09:24

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

Published on: October 6, 2022

3.4K
A Closed-chest Model to Induce Transverse Aortic Constriction in Mice08:10

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

Published on: April 5, 2018

18.9K

Related Concept Videos

Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
3
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
2
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
2
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1