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Insights into CSF-1R Expression in the Tumor Microenvironment.

Caterina Tomassetti1,2, Gaia Insinga3, Francesca Gimigliano3

  • 1Department of Biotechnology Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.

Biomedicines
|October 26, 2024
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Summary

The colony-stimulating factor 1 receptor (CSF-1R) is crucial in the tumor microenvironment, affecting various cells like macrophages and cancer stem cells. Targeting CSF-1R may disrupt tumor growth and enhance immune responses.

Keywords:
CAFsCSF-1RECsMDSCsTAMscancer stem cellstumor microenvironment

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Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • The colony-stimulating factor 1 receptor (CSF-1R) is vital for cell communication in the tumor microenvironment (TME).
  • While its role in myeloid cells is known, its function in other TME cells requires further investigation.

Purpose of the Study:

  • To review the diverse roles of CSF-1R in various tumor-associated cell types.
  • To highlight CSF-1R's potential as a therapeutic target in cancer treatment.

Main Methods:

  • Literature review of studies on CSF-1R expression and function in TME cells.
  • Analysis of CSF-1R signaling pathways and their impact on cellular interactions.

Main Results:

  • CSF-1R activation by CSF-1 and IL-34 influences tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and dendritic cells (DCs).
  • CSF-1R in cancer-associated fibroblasts (CAFs), endothelial cells (ECs), and cancer stem cells (CSCs) impacts angiogenesis, immune modulation, and therapeutic resistance.
  • CSF-1R signaling promotes tumor progression, immune evasion, and aggressiveness.

Conclusions:

  • CSF-1R plays multifaceted roles across various TME cell populations.
  • Targeting CSF-1R offers a promising strategy to disrupt pro-tumorigenic crosstalk and boost anti-tumor immunity.