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Update/Refinement of Targeted Muscle Reinnervation Indication: A Scoping Review of Applications for Non-Amputees
Jonathan Cornacchini1,2, Haïzam Oubari2,3, Vlad Tereshenko4
1Department of Plastic and Reconstructive Surgery, Pasteur University Hospital, 06000 Nice, France.
Journal of Clinical Medicine
|October 26, 2024
Summary
Targeted muscle reinnervation (TMR) shows promise for treating neuropathic pain and neuromas in non-amputees. This surgical approach offers pain relief and improves psychosocial well-being with low complication rates.
Area of Science:
- Neurosurgery
- Pain Management
- Regenerative Medicine
Background:
- Targeted muscle reinnervation (TMR) was initially for prosthetic control in amputees.
- TMR has shown benefits in reducing phantom pain and neuromas.
- It is now explored for chronic neuropathic pain and neuromas in non-amputees.
Purpose of the Study:
- To review current literature on TMR for non-amputee patients.
- To highlight TMR's potential for chronic peripheral nerve pain and neuromas.
- To synthesize evidence beyond TMR's original application in amputation.
Main Methods:
- Systematic literature search of PubMed and Cochrane databases (up to Jan 2024).
- Adherence to PRISMA guidelines for study selection.
- Inclusion of case series, cohort studies, and RCTs on TMR in non-amputees.
Main Results:
- Eight studies met inclusion criteria, primarily case series.
- Focus on neuroma treatment (6 studies) and neuropathic pain (2 studies).
- Demonstrated pain relief, improved function, patient satisfaction, and psychosocial benefits with low morbidity.
Conclusions:
- TMR is a promising surgical option for non-amputees with neuropathic pain and neuromas.
- Favorable patient satisfaction and psychosocial outcomes observed.
- Further research needed to confirm functional improvements and expand applications.
