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Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the appropriate...
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Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
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Porous Silicon Microparticles for Delivery of siRNA Therapeutics
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Biomimetic Nanoparticles for Basic Drug Delivery.

Andrey Tikhonov1, Artyom Kachanov1, Alexandra Yudaeva1

  • 1Laboratory of Genetic Technologies, Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.

Pharmaceutics
|October 26, 2024
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Biomimetic nanoparticles (BMNPs) mimic natural vesicles for efficient, biocompatible drug delivery. This review covers their preparation, functionalization, and challenges for clinical use.

Keywords:
RNAcargodelivery vehiclestargeted deliverytherapeutics

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Biomimetic nanoparticles (BMNPs) leverage natural extracellular vesicle properties for advanced drug delivery.
  • They offer enhanced biocompatibility and reduced toxicity compared to conventional nanocarriers.
  • BMNPs can encapsulate therapeutic payloads and modify existing nanotechnologies.

Purpose of the Study:

  • To provide a comprehensive overview of biomimetic nanoparticle preparation and functionalization.
  • To analyze various BMNP types, including cell membrane-coated nanoparticles (CMCNPs), artificial cell-derived vesicles (ACDVs), and fully synthetic vesicles (fSVs).
  • To discuss challenges and solutions for large-scale production and clinical translation of BMNPs.

Main Methods:

  • Review of "top-down" and "bottom-up" nanoparticle fabrication approaches.
  • Focus on techniques like cell membrane coating, cargo loading, and microfluidic fabrication.
  • Analysis of functionalization strategies for enhanced therapeutic efficacy.

Main Results:

  • BMNPs demonstrate potential for overcoming biological barriers and targeting specific organs/tissues.
  • Coating nanoparticles with biological membranes significantly improves therapeutic outcomes.
  • Various methods exist for preparing and functionalizing BMNPs for diverse applications.

Conclusions:

  • BMNPs represent a promising frontier in drug delivery technology due to their inherent biocompatibility and targeting capabilities.
  • Addressing challenges in large-scale manufacturing and clinical application is crucial for realizing the full potential of BMNPs.
  • Continued research into biomimetic technologies will drive innovation in nanomedicine.