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Updated: May 7, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

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Published on: May 14, 2013

Provinols™, a Polyphenolic Extract of Red Wine, Inhibits In-Stent Neointimal Growth in Cholesterol-Fed Rabbit.

Meyer Elbaz¹, Gérald Roul², Ramaroson Andriantsitohaina³

¹Department of Cardiology, Institute CARDIOMET, University Hospital of Toulouse, 31059 Toulouse, France.

|October 26, 2024

Summary

Red wine polyphenols (Provinols™) reduced neointimal hyperplasia and lipid deposition in hypercholesterolemic rabbits after stenting. This suggests potential benefits for preventing restenosis and cardiovascular disorders.

Keywords:

polyphenols supplementation restenosis stent

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Area of Science:

Cardiovascular Research
Pharmacology
Nutraceuticals

Background:

Epidemiological studies suggest polyphenols may reduce cardiovascular disease risk.
Neointimal hyperplasia is a key factor in restenosis after angioplasty.

Purpose of the Study:

To investigate the efficacy of a red wine polyphenol extract (Provinols™) in reducing neointimal hyperplasia.
To evaluate Provinols™ in a hypercholesterolemic rabbit model post-angioplasty and stenting.

Main Methods:

Hypercholesterolemic rabbits underwent iliac balloon injury and stenting.
Rabbits received oral Provinols™ (20 mg/kg/day) or placebo for four weeks.
Histological analysis assessed neointimal hyperplasia, lipid deposition, and inflammation.

Main Results:

Provinols™ did not significantly alter blood pressure or plasma cholesterol.
A notable reduction in neointimal growth, thickness, and surface area was observed.
Reduced arterial fat accumulation and inflammatory response were associated with Provinols™ treatment.

Conclusions:

Oral Provinols™ shows potential in reducing in-stent neointimal hyperplasia and lipid deposition.
Anti-inflammatory properties likely contribute to the observed effects in hypercholesterolemic rabbit iliac arteries.
Findings support the therapeutic potential of plant-derived polyphenols for preventing restenosis after stent placement.