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Clindamycin-Loaded Polyhydroxyalkanoate Nanoparticles for the Treatment of Methicillin-Resistant Staphylococcus

Muneeb Ullah1, Juho Lee1, Nurhasni Hasan2

  • 1College of Pharmacy, Pusan National University, Busandaehak-ro 63 beon-gil 2, Geoumjeong-gu, Busan 46241, Republic of Korea.

Pharmaceutics
|October 26, 2024
PubMed

Insights

Novel clindamycin-loaded polyhydroxyalkanoate nanoparticles (Cly-PHA NPs) effectively treat methicillin-resistant Staphylococcus aureus (MRSA) wound infections. These nanoparticles accelerate healing by eradicating MRSA and providing sustained drug release.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Infectious Diseases

Background:

  • Growing antibiotic resistance in methicillin-resistant Staphylococcus aureus (MRSA) necessitates novel therapeutic strategies.
  • Developing effective treatments for MRSA-infected cutaneous wounds remains a significant clinical challenge.

Purpose of the Study:

  • To develop and evaluate clindamycin-loaded polyhydroxyalkanoate nanoparticles (Cly-PHA NPs) for treating MRSA-infected cutaneous wounds.
  • To assess the physicochemical properties, drug release kinetics, antibacterial efficacy, and wound healing potential of Cly-PHA NPs.

Main Methods:

  • Polyhydroxyalkanoates (PHA) were utilized to create clindamycin-loaded nanoparticles (Cly-PHA NPs).
  • Nanoparticle characterization included particle size, polydispersity index, zeta potential, and drug loading.
  • In vitro antibacterial activity against MRSA and in vivo wound healing efficacy in a mouse model were evaluated.

Main Results:

  • Cly-PHA NPs demonstrated a mean particle size of 216.2 ± 38.9 nm and drug loading of 6.76 ± 0.19%.
  • Sustained release of clindamycin from PHA over 2 days was observed, leading to potent antibacterial effects against MRSA.
  • Cly-PHA NPs significantly accelerated wound healing in a mouse model by eradicating MRSA.

Conclusions:

  • Clindamycin-loaded PHA nanoparticles represent a promising therapeutic approach for MRSA infections.
  • Cly-PHA NPs effectively combat MRSA and promote accelerated cutaneous wound healing.
Keywords:
MRSA-infected cutaneous woundsclindamycinnanoparticlespolyhydroxyalkanoates

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