Related Experiment Video

Updated: Jun 9, 2025

Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog
08:37

Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog

Published on: November 5, 2014

9.9K

The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance

Qing Wang1, Hsin-Sheng Yang1,2

  • 1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA.

Pharmaceuticals (Basel, Switzerland)
|October 26, 2024
PubMed

Insights

Programmed cell death 4 (Pdcd4) is a tumor suppressor that inhibits protein translation. Pdcd4 also enhances anticancer drug effectiveness by regulating key cellular pathways, potentially overcoming drug resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Programmed cell death 4 (Pdcd4) functions as a tumor suppressor, inhibiting cancer development.
  • Pdcd4 biochemically interacts with translation initiation factor 4A, repressing protein synthesis.
  • Emerging evidence highlights Pdcd4's role in augmenting chemosensitivity to various anticancer agents.

Purpose of the Study:

  • To review signal transduction pathways regulated by Pdcd4.
  • To explore mechanisms by which Pdcd4 enhances chemosensitivity.
  • To discuss how Pdcd4 may overcome drug resistance in cancer therapy.

Main Methods:

  • Literature review of studies on Pdcd4.
  • Analysis of identified translational targets of Pdcd4.
  • Discussion of signal transduction pathways influenced by Pdcd4.

Main Results:

  • Pdcd4 targets numerous proteins involved in crucial signaling pathways.
  • Attenuation of these Pdcd4 targets is linked to improved chemosensitivity.
  • Pdcd4's regulatory functions are key to its tumor-suppressive and chemosensitizing activities.

Conclusions:

  • Pdcd4 plays a multifaceted role in cancer, acting as a tumor suppressor and chemosensitizer.
  • Understanding Pdcd4-regulated pathways offers therapeutic strategies to enhance cancer treatment.
  • Targeting Pdcd4 or its downstream effectors may be a viable approach to combat drug resistance.
Keywords:
IGF1R/IR inhibitorJNK pathwaydoxorubicineIF4AfluorouracilmTORC2–Akt pathwaypaclitaxelplatinum-containing drugβ-catenin pathway

More Related Videos

Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype14:51

Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype

Published on: June 17, 2022

3.2K
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

10.5K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.7K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Factors Affecting Drug Distribution: Physiological Barriers01:23

Factors Affecting Drug Distribution: Physiological Barriers

Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
178
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
227