Related Experiment Video
Updated: Jun 29, 2026
Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Ansa-Ferrocene Derivatives as Potential Therapeutics
Marcin Cybulski1, Olga Michalak1, Włodzimierz Buchowicz2
1Chemistry Section, Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, Rydygiera 8, 01-793 Warsaw, Poland.
Abstract:
It has been known since the 1990s that the introduction of a ferrocenyl-type substituent into compounds with proven biological activity can improve their properties. More recently, it was also shown that a carbon bridge connecting the two cyclopentadienyl rings in ferrocene derivatives could enhance the biological properties of the new compounds compared to those without them. However, the synthesis of ferrocenes with this additional linker, known as ansa-ferrocenes, is more difficult due to advanced synthetic protocols and the phenomenon of planar chirality in ring-substituted compounds. As a result, research into the formation of hybrids, conjugates and other ansa-ferrocene derivatives has not been widely conducted. This review discusses the potential biological properties of these units, covering scientific articles published between 1980 and 2024.
More Related Videos
Related Concept Videos
01:16Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
01:28Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...