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Related Experiment Video

Updated: Apr 26, 2026

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Virucidal Coatings Active Against SARS-CoV-2.

Anna I Barabanova¹, Eduard V Karamov², Viktor F Larichev²

¹Institute of Organoelement Compounds, 119991 Moscow, Russia.

Molecules (Basel, Switzerland)

|October 26, 2024

Summary

Antiviral coatings with release-based or combined actions effectively inactivate SARS-CoV-2. Contact-based coatings showed limited efficacy, suggesting free disinfectants are more potent against the virus.

Keywords:

COVID-19 SARS-CoV-2 cationic surfactants disinfectants quaternary ammonium compounds virus inactivation

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Last Updated: Apr 26, 2026

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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Published on: November 5, 2021

Engineering Antiviral Agents via Surface Plasmon Resonance

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Published on: June 14, 2022

Determining Viral Disinfection Efficacy of Hot Water Laundering

Determining Viral Disinfection Efficacy of Hot Water Laundering

Published on: June 21, 2022

Area of Science:

Materials Science
Virology
Surface Chemistry

Background:

Quaternary ammonium compounds are widely used disinfectants.
Developing effective antiviral surfaces is crucial for infection control.

Purpose of the Study:

To evaluate the efficacy of different quaternary ammonium surfactant-based coatings against SARS-CoV-2.
To compare contact-based, release-based, and combined action coatings for antiviral activity.

Main Methods:

Preparation of glass and silicon surfaces with covalently attached or non-covalently bound quaternary ammonium surfactants.
Surface characterization using attenuated total reflection infrared spectroscopy, X-ray photoelectron spectroscopy (XPS), scanning electron microscopy, and contact angle measurements.
SARS-CoV-2 inactivation assessed via virus titration.

Main Results:

Combined and release-based action coatings completely inactivated SARS-CoV-2.
Contact-based coatings showed limited efficacy (up to 1.25 log10 reduction) due to low disinfectant density.
Binding disinfectants to surfaces, especially nanoparticles, reduced their antiviral activity compared to free disinfectants.

Conclusions:

Surfaces utilizing release-based or combined inactivation mechanisms are highly effective against SARS-CoV-2.
Covalently bound disinfectants in a monolayer are less effective than those with release capabilities.
Free disinfectants demonstrate higher potency against SARS-CoV-2 compared to surface-bound ones.