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Related Experiment Video

Updated: Jun 9, 2025

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
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Cannabis Use during Pregnancy: An Update.

Angeliki Gerede1, Sofoklis Stavros2, Christos Chatzakis3

  • 1Unit of Maternal-Fetal-Medicine, Department of Obstetrics and Gynecology, Medical School, Democritus University of Thrake, 8100 Alexandroupolis, Greece.

Medicina (Kaunas, Lithuania)
|October 26, 2024
PubMed
Summary

Prenatal cannabis exposure poses significant risks to fetal neurodevelopment, leading to cognitive and behavioral issues in children. Addressing this requires integrated public health strategies to protect maternal and child well-being.

Keywords:
long-term developmental outcomesmaternal health risksneurodevelopmental outcomesplacental functionprenatal cannabis exposurepublic health policy

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Area of Science:

  • Obstetrics and Gynecology
  • Neuroscience
  • Public Health

Background:

  • Cannabis use during pregnancy is a growing concern.
  • Prenatal cannabis exposure has potential adverse effects on maternal and fetal health.
  • Neurodevelopmental outcomes are a key area of focus.

Purpose of the Study:

  • To review the dangers of prenatal cannabis exposure, focusing on neurodevelopment.
  • To discuss maternal and placental factors affecting offspring development.
  • To synthesize current literature on the topic.

Main Methods:

  • Comprehensive literature search for pertinent and up-to-date materials.
  • Review of studies on prenatal cannabis exposure and its effects.
  • Analysis of longitudinal data on developmental outcomes.

Main Results:

  • Prenatal cannabis exposure is linked to cognitive impairments and behavioral difficulties.
  • Structural and functional brain alterations are observed in offspring.
  • Increased risks of pregnancy complications (e.g., preterm birth, low birth weight) and negative impacts on placental function and fetal growth.

Conclusions:

  • Prenatal cannabis exposure has substantial hazards, including long-term developmental challenges.
  • A coordinated strategy involving public health policy, education, and research is essential.
  • Mitigating these risks is crucial for current and future generations' health and welfare.