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Mortality Impact of Severe COVID-19 in the ICU: A Study from the Târgu Mureș Support Unit

Janos Szederjesi1, Irina Săplăcan1, Marius Petrișor2

  • 1Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Târgu-Mureș, Romania.

Life (Basel, Switzerland)
|October 26, 2024
PubMed

Insights

Critically ill COVID-19 patients face high mortality, with severe comorbidities being the primary driver. Specialized care units show limited survival benefits, highlighting the need for better treatment strategies for severe SARS-CoV-2 infections.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • The COVID-19 pandemic has led to significant mortality in critically ill patients.
  • Specialized COVID-19 care units were established to manage severe cases.
  • Understanding long-term outcomes in these units is crucial for evaluating care efficacy.

Purpose of the Study:

  • To assess the 1-year outcomes of patients treated in a specialized COVID-19 unit.
  • To identify factors associated with mortality in critically ill COVID-19 patients.
  • To evaluate the effectiveness of intensive care in managing severe SARS-CoV-2 infection.

Main Methods:

  • Retrospective, monocentric observational study.
  • Inclusion of 294 patients with confirmed SARS-CoV-2 infection.
  • Assessment of demographic, clinical, and paraclinical data; Kaplan-Meier survival analysis.

Main Results:

  • 1-year mortality rate was 89.4%, with all deaths occurring in-hospital.
  • Deceased patients had higher prevalence of diabetes, chronic kidney failure, cerebrovascular disease, and atrial fibrillation.
  • Higher incidence of hospital-acquired pneumonia and significant differences in SOFA scores were observed between deceased and survivor groups.

Conclusions:

  • Severe comorbidities are the primary contributors to high mortality in this COVID-19 unit.
  • Intensive care management in specialized units had limited impact on overall survival for severely ill patients.
  • Further research into managing patients with multiple comorbidities and severe COVID-19 is warranted.

Keywords:
COVID19SARS-CoV-2mortality

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