Related Experiment Video
Updated: Jun 9, 2025

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
Published on: August 17, 2022
Lymphocyte to White Blood Cell Count Ratio an Independent Risk Factor for Heart Failure
Lior Charach1, Avishay Spitzer2, Lior Zusmanovitch3
1Division of Gastroenterology, Laniado Medical Center, Netanya 4244916, Israel.
The lymphocyte-to-white-blood-cell ratio (LWR) can predict survival in heart failure patients. A low LWR (< 0.2) indicates significantly increased mortality risk, while a high LWR (> 0.35) is linked to better long-term survival.
Area of Science:
- Cardiology
- Hematology
- Biomarkers
Background:
- Heart failure impacts 1-2% of developed country populations.
- Hemogram biomarkers offer cost-effective, rapid prognostic insights in various diseases.
- Existing biomarkers for heart failure prognosis are limited.
Purpose of the Study:
- To investigate the lymphocyte-to-white-blood-cell ratio (LWR) as a prognostic predictor in heart failure patients.
- To determine the association between LWR levels and long-term survival in heart failure.
Main Methods:
- A cohort of heart failure patients was recruited between January 2000 and July 2001.
- Patients with malignancy or specific treatments affecting blood counts were excluded.
- Patients were stratified into three groups based on LWR: < 0.2, 0.2-0.35, and > 0.35.
Main Results:
- 305 patients (mean age 70.1 ± 10.8 years, 73% male) were analyzed.
- The lowest LWR group (< 0.2) exhibited the poorest survival rates.
- The highest LWR group (> 0.35) demonstrated the best long-term survival outcomes.
Conclusions:
- A lymphocyte-to-white-blood-cell ratio (LWR) below 0.2 is associated with significantly increased mortality in heart failure.
- LWR serves as an independent prognostic predictor for heart failure patients.
- LWR demonstrates prognostic value comparable to or exceeding established parameters like CRP, NYHA, EF, and LDL.
More Related Videos
09:20Intracellular Staining and Flow Cytometry to Identify Lymphocyte Subsets within Murine Aorta, Kidney and Lymph Nodes in a Model of Hypertension
Published on: January 28, 2017
07:39Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
Published on: January 7, 2019
Related Concept Videos
Heart Failure I: Introduction
Pathophysiology of Heart Failure
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Heart Failure IV: Classification and Diagnostic Evaluation
Heart Failure II: Pathophysiology
Structure and Function of Leukocytes
White blood cells protect the body...