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Correlations between Apparent Diffusion Coefficient (ADC) and Prognosis in Patients with Locally Advanced Rectal Cancer

  • 0Department of Diagnostic Radiology, IRCCS Fondazione San Gerardo dei Tintori, Via Pergolesi 33, 20900 Monza, MB, Italy.
Life (basel, Switzerland) +

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October 26, 2024

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October 26, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values show promise in predicting treatment response and prognosis for locally advanced rectal cancer. Post-treatment ADC values can predict histopathological response, aiding in conservative treatment planning.

Area Of Science

  • Radiology
  • Oncology
  • Medical Imaging

Background

  • Locally advanced rectal cancer (LARC) requires effective prediction of treatment response.
  • Neoadjuvant chemoradiation therapy (CRT) is a standard treatment for LARC.
  • Assessing treatment response and patient outcomes is crucial for optimizing LARC management.

Purpose Of The Study

  • To evaluate the efficacy of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values in predicting neoadjuvant CRT response in LARC patients.
  • To determine the correlation between ADC values and tumor regression grade (TRG) and overall survival (OS).

Main Methods

  • Retrospective analysis of 94 LARC patients who underwent MRI before and after neoadjuvant CRT.
  • Manual region of interest (ROI) placement on DWI sequences to derive mean ADC values.
  • Correlation analysis of pre- and post-treatment ADC values with Mandard TRG and pTNM staging.
  • Assessment of ADC values in relation to overall survival (OS).

Main Results

  • Post-treatment ADC and ΔADC values significantly correlated with TRG classes (p=0.002 and p=0.019, respectively).
  • Post-treatment ADC values differed significantly between responders and non-responders (p=0.019).
  • Pre-treatment ADC values negatively correlated with OS (p=0.001), while ΔADC positively correlated with OS (p=0.013).

Conclusions

  • Pre-treatment ADC and ΔADC values can serve as prognostic predictors for LARC patients.
  • Post-treatment ADC values are valuable for predicting histopathological response and guiding conservative treatment strategies.
  • ADC parameters derived from DWI show potential for personalized treatment planning in LARC.

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