Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Anticancer Effects Of Weizmannia Coagulans Mzy531 Postbiotics In Ct26 Colorectal Tumor-bearing Mice By Regulating Apoptosis And Autophagy

Anticancer Effects of Weizmannia coagulans MZY531 Postbiotics in CT26 Colorectal Tumor-Bearing Mice by Regulating Apoptosis and Autophagy

Bao Zhong1,2, Yujuan Zhao1, Lei Gao1

  • 1Institute of Agro-Food Technology, Jilin Academy of Agricultural Sciences (Northeast Agricultural Research Center of China), Changchun 130033, China.

Life (Basel, Switzerland)
|October 26, 2024

Related Experiment Videos

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

823
Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

8.4K
Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
09:03

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

338

View abstract on PubMed

Summary
This summary is machine-generated.

Postbiotic Weizmannia coagulans MZY531 effectively inhibits colorectal cancer growth by promoting apoptosis and modulating autophagy. This study reveals its significant impact on tumor markers and key cellular pathways.

Area of Science:

  • Microbiology
  • Oncology
  • Cell Biology

Background:

  • Weizmannia coagulans exhibits anticancer properties, but its postbiotic effects on colorectal cancer (CRC) require further investigation.
  • The precise mechanisms by which W. coagulans postbiotics influence apoptosis and autophagy in CRC remain unclear.

Purpose of the Study:

  • To investigate the role of W. coagulans MZY531 postbiotics in inhibiting CRC tumor growth.
  • To elucidate the mechanisms involving apoptosis and autophagy modulation by W. coagulans MZY531 postbiotics.

Main Methods:

  • Tumor models were used to assess the effects of W. coagulans MZY531 postbiotics on tumor proliferation and markers.
  • Immunofluorescence and Western blot analyses were employed to evaluate apoptosis (caspase-3, TUNEL, Bax/Bcl-2, JAK2/STAT3) and autophagy (PI3K/AKT/mTOR, TGF-β/SMAD4) pathways.
Keywords:
Weizmannia coagulansapoptosisautophagycolorectal cancer

Related Experiment Videos

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

823
Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

8.4K
Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
09:03

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

338

Main Results:

  • W. coagulans MZY531 postbiotics significantly reduced tumor markers (CEA, CCA, PKA) and increased apoptosis markers (caspase-3, TUNEL).
  • Postbiotic treatment modulated key apoptosis pathways (Bax/Bcl-2/caspase-3, JAK2/STAT3) and autophagy pathways (PI3K/AKT/mTOR, TGF-β/SMAD4).
  • The effects of W. coagulans MZY531 postbiotics were more pronounced than those of W. coagulans MZY531 alone.

Conclusions:

  • W. coagulans MZY531 postbiotics demonstrate significant potential in inhibiting colorectal cancer progression.
  • Modulation of apoptosis and autophagy pathways are key mechanisms underlying the anti-tumor effects of W. coagulans MZY531 postbiotics.
  • W. coagulans postbiotics show promise as functional foods for colorectal cancer management.
postbiotics