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The Management of Hematopoietic Stem Cell Transplant in People with HIV

Jana K Dickter1, Courtney Moc Willeford2

  • 1Division of Infectious Diseases, Department of Medicine, City of Hope National Medical Center, Duarte, CA 91010, USA.

Viruses
|October 26, 2024
PubMed

Hematopoietic stem cell transplant (HSCT) is now recognized as a standard treatment option for people with HIV (PWH) who develop high-risk hematologic malignancies. However, the involved polypharmacy can lead to complications from drug interactions and toxicities, affecting the efficacy and safety of chemotherapy and antiretroviral therapy (ART). Managing these patients requires a personalized approach, including the careful selection of ART based on previous therapies and potential interactions, alongside risk assessment for infections. This discussion will address the history of HSCT in PWH and management considerations for this group.

Keywords:
HIVhematologic malignancyhematopoietic stem cell transplantopportunistic infection

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