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Why is fresh-frozen plasma transfused?

A J Snyder, J L Gottschall, J E Menitove

    Transfusion
    |January 1, 1986
    PubMed
    Summary

    Fresh-frozen plasma (FFP) is primarily used for coagulation factor replacement, often without clear documentation in patient records. Clinicians perceive FFP transfusions as effective, highlighting a need for educational initiatives on appropriate use.

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    Area of Science:

    • Transfusion Medicine
    • Hematology
    • Clinical Pathology

    Background:

    • Fresh-frozen plasma (FFP) is a common blood product transfusion.
    • Understanding the indications and documentation for FFP use is crucial for optimizing patient care and resource allocation.

    Purpose of the Study:

    • To investigate the primary reasons for fresh-frozen plasma (FFP) transfusions in southeastern Wisconsin hospitals.
    • To assess the documentation and perceived effectiveness of FFP transfusions.

    Main Methods:

    • A three-part study involving transfusion data analysis and clinician surveys.
    • Review of patient records for FFP transfusion justification and associated clinical findings.
    • Questionnaire-based assessment of clinician triggers for FFP prescription.

    Main Results:

    • Open-heart surgery patients received the largest proportion of FFP (42%).
    • Documentation for FFP transfusions was lacking in most cases (only 11% provided justification).
    • Clinicians cited bleeding (43%) and abnormal coagulation studies (26%) as primary reasons for FFP use, perceiving it as effective in 47% of episodes.

    Conclusions:

    • FFP is predominantly used for coagulation factor replacement in the studied region.
    • There is a significant gap in documenting the rationale for FFP transfusions.
    • Educational interventions are recommended to promote appropriate FFP utilization and improve transfusion practices.

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