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Differences in Susceptibility to SARS-CoV-2 Infection Among Transgenic hACE2-Hamster Founder Lines.

Scott A Gibson1,2, Yanan Liu1, Rong Li1

  • 1Department of Animal, Diary and Veterinary Sciences, Utah State University, Logan, UT 84322, USA.

Viruses
|October 26, 2024
PubMed
Summary

Transgenic hamsters expressing human angiotensin-converting enzyme 2 (hACE2) provide a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) model. Prophylactic treatment with polyinosinic-polycytidylic acid (Poly (I:C)) improved survival in highly susceptible hACE2 transgenic hamsters.

Keywords:
SARS-CoV-2animal modeltransgenic hamsterviral pathogenesis

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