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Non-coding RNAs: Key regulators of CDK and Wnt/β-catenin signaling in cancer

Mohammad Arshad Javed Shaikh1, M Arockia Babu2, Nehmat Ghaboura3

  • 1Department of Pharmacy, TPCT's College of Engineering, Osmanabad, Maharashtra, India.

Pathology, Research and Practice
|October 26, 2024
PubMed

Insights

Non-coding RNAs (ncRNAs) significantly impact cancer by modulating gene expression and key signaling pathways like Wnt/β-catenin and cyclin-dependent kinases (CDKs). Understanding these ncRNA roles offers new diagnostic and therapeutic strategies for cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Non-coding RNAs (ncRNAs) are crucial regulators of gene expression and biological processes.
  • ncRNAs play a significant role in cancer initiation and progression.
  • Wnt/β-catenin signaling and cyclin-dependent kinases (CDKs) are critical pathways implicated in cancer.

Purpose of the Study:

  • To review the intricate interactions between ncRNAs and the Wnt/β-catenin and CDK signaling pathways in cancer.
  • To explore how different classes of ncRNAs (miRNAs, lncRNAs, circRNAs) modulate these pathways.
  • To highlight the role of ncRNAs in cancer cell survival, proliferation, metastasis, drug resistance, and as diagnostic/therapeutic targets.

Main Methods:

  • Literature review of current research on ncRNA modulation of Wnt/β-catenin and CDK pathways in various cancer types.
  • Analysis of mechanisms by which ncRNAs regulate cancer cell functions.
  • Discussion of ncRNAs' implications in cancer treatment outcomes and prognosis.

Main Results:

  • ncRNAs extensively modulate Wnt/β-catenin and CDK signaling pathways across diverse cancers.
  • Specific ncRNAs influence cancer cell survival, proliferation, and metastasis through these pathways.
  • ncRNAs are implicated in cancer drug resistance and serve as potential biomarkers and therapeutic targets.

Conclusions:

  • ncRNAs are key players in cancer development and progression via Wnt/β-catenin and CDK pathways.
  • Targeting ncRNAs presents promising avenues for improved cancer diagnosis and treatment.
  • Further understanding of these regulatory networks is vital for advancing cancer research and patient care.
Keywords:
Cyclin-dependent kinaseGene expressionNcRNAsPrognosis markersWnt/β-catenin

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