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Neoadjuvant treatment in locally advanced rectal cancer with deficient mismatch repair (dMMR): a paradigm shift

Alba Manuel-Vázquez1, Miguel Soria Tristán2, José Miguel Martín Martínez2

  • 1Departamento de Medicina, Facultad de Ciencias Biomédicas y de la Salud, Universidad Europea de Madrid, Spain; Unidad de Coloproctología, Cirugía General y del Aparato Digestivo, Hospital Universitario de Getafe, Spain.

Cirugia Espanola
|October 26, 2024
PubMed
Abstract

No abstract available in PubMed .

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Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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