Related Experiment Video
Updated: Jun 9, 2025

Postoperative Ileus Murine Model
Published on: July 12, 2024
Postoperative ileus-Immune mechanisms and potential therapeutic interventions
Zheng Wang1, Nathalie Stakenborg1, Guy Boeckxstaens1
1Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven-University of Leuven, Leuven, Belgium.
Background:
Postoperative ileus (POI) is a condition marked by a temporary suppression of gastrointestinal motility following abdominal surgery. The mechanism of POI encompasses various factors and is characterized by two phases: the early neurogenic phase involving both adrenergic and non-adrenergic neural pathways; the later immune-mediated phase is characterized by a sterile inflammatory response that lasts several days. Activation of muscularis macrophages triggers a sterile inflammatory process that results in dysfunction of the enteric nervous system (ENS) and a reversible inhibition of gastrointestinal motility.
Purpose:
In this minireview, recent insights in the pathophysiological mechanisms underlying POI and potential new therapeutic strategies are described.
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