Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Extremely Rare and Devastating Complication of Penetrating Keratoplasty: Postoperative Endophthalmitis Because of Carbapenem-Resistant Klebsiella pneumoniae.

Eye & contact lens·2026
Same author

Determinants of extraction efficiency in human amniotic membrane processing: biological, mechanical, and biochemical factors shaping growth factor yield.

Cell and tissue banking·2026
Same author

Unilateral posterior polymorphous corneal dystrophy in infancy.

Clinical & experimental optometry·2026
Same author

Revisiting the ocular use of chlorhexidine: an agent to remember in multidrug-resistant bacterial and fungal keratitis.

International ophthalmology·2026
Same author

A novel method for managing advanced zonular dialysis: Sclerocorneal flanged monofixation of intraocular lens and capsular bag complex.

European journal of ophthalmology·2026
Same author

Tracing acanthamoeba in a third-trimester pregnant woman with keratitis.

Clinical & experimental optometry·2026

Related Experiment Video

Updated: Jun 26, 2026

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse
04:55

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

Published on: November 17, 2016

8.3K

Evaluation of Medically Reversible Limbal Stem Cell Deficiency.

İlayda Korkmaz1, Nihat Furkan Eratılgan1, Melis Palamar1

  • 1Ege University Faculty of Medicine, Department of Ophthalmology, İzmir, Türkiye.

Turkish Journal of Ophthalmology
|October 28, 2024
PubMed
Summary

Medical therapy can reverse limbal stem cell deficiency (LSCD) in many patients. Early-stage LSCD, particularly when inflammation is a factor, may not require surgical intervention for successful treatment.

Keywords:
Limbal stem cell deficiencymarginal keratitisocular rosacea

More Related Videos

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration
07:39

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration

Published on: August 4, 2023

1.9K
Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research
10:11

Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research

Published on: October 27, 2023

961

Related Experiment Videos

Last Updated: Jun 26, 2026

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse
04:55

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

Published on: November 17, 2016

8.3K
Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration
07:39

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration

Published on: August 4, 2023

1.9K
Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research
10:11

Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research

Published on: October 27, 2023

961

Area of Science:

  • Ophthalmology
  • Stem Cell Biology
  • Corneal Disease

Background:

  • Limbal stem cell deficiency (LSCD) is a serious condition affecting corneal health.
  • Current treatments often involve invasive procedures like stem cell transplantation.
  • Understanding medical management options is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the effectiveness of medical therapy in managing patients with LSCD.
  • To analyze the clinical characteristics and treatment strategies for LSCD managed non-surgically.
  • To determine if medical treatment can halt or reverse LSCD progression.

Main Methods:

  • Retrospective analysis of 21 LSCD patients (29 eyes) treated medically.
  • Assessment of LSCD stages before and after treatment using the International LSCD Working Group staging system.
  • Evaluation of patients who improved without surgical intervention.

Main Results:

  • The primary causes of LSCD were ocular rosacea (57.1%) and blepharitis-associated marginal keratitis (38.1%).
  • Complete LSCD regression occurred in 20.7% of eyes with medical treatment.
  • In other cases, medical therapy reduced LSCD severity below the surgical threshold (stage 2B).
  • Best corrected visual acuity improved significantly from 0.25±0.26 logMAR to 0.07±0.1 logMAR.

Conclusions:

  • LSCD can be reversible with appropriate medical management, especially when inflammation is involved.
  • Early-stage or localized LSCD may be effectively treated with medical therapy alone.
  • Medical management offers a viable alternative to surgery for select LSCD patients.